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Course Details

Fall 2011-2012
CHM 515  

Biophysical Chemistry I

Jannette Carey

This course provides a comprehensive introduction to basic principles of macromolecular structure, stability, and interactions. Major topics include protein structure; protein thermodynamics and folding; nucleic acid structure and stability; principles of intermolecular recognition; and principles and practice of ligand binding analysis. Special emphasis is placed on understanding, in macromolecular systems, the relationships between structure and stability; the molecular origins of cooperative effects; and the relationships between covalent and non-covalent properties.

Sample reading list:
Klotz, I.M. (1997), Ligand-receptor energetics: A guide for the perplexed
Cantor & Schimmel, Biophysical Chemistry I, II, III
Miscellaneous specialized texts,
Topical readings from the research literature,

Other information:
The course is intended for beginning graduate students or advanced undergraduates in chemistry, computer science, mathematics, molecular biology, physics, or engineering. Some basic background in undergraduate chemistry is assumed, but there are no specific prerequisites. There will be a midterm exam and a final paper.

Schedule/Classroom assignment:

Class numberSectionTimeDaysRoomEnrollmentStatus
22282 L01 1:30 pm - 2:50 pm T Th   Lewis Library   134   Enrolled:1 Limit:30