CHM 544 / ENV 544
Metals in Biology
Life processes depend on over 25 elements whose bioinorganic chemistry is relevant to the environment (biogeochemical cycles), agriculture, and health. Chem 544 surveys the bioinorganic chemistry of the elements. In-depth coverage of key transition metal ions including manganese, iron, copper, and molybdenum focuses on redox roles in anaerobic and aerobic systems and metalloenzymes that activate small molecules and ions, including hydrogen, nitrogen, nitrate, nitric oxide, oxygen, superoxide, and hydrogen peroxide. Appreciation of the structure and reactivity of metalloenzyme systems is critical to understanding life at the molecular level.
Sample reading list:
Stephen J. Lippard, Jeremy M. Berg, Principles of Bioinorganic Chemistry, University Books, Mill
J. J. R. Fraústo da Silva, R. J. P. Williams, Biological Chem. of Elements:The Inorg. Chem. of Life 2nd Ed
W. Kaim, B. Schwederski, Bioinorg. Chem.: Inorg. Elem'ts in the Chem. of Life 2nd Ed.
Bertini, Gray, Stiefel, & Valentine - Univ Science 2006, Biological Inorganic Chemistry: Structure & Reactivity
R. J. P. Williams, J. J. R. Fraústo da Silva, The Natural Selection of the Chemical Elements
Not Open to Freshmen.
Prerequisites: CHM 301/302 or CHM 303/304
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