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What should students know about their genes and genomes? Today, the field of Human Genetics is explored and debated like no other. To understand the medical applications and ethical implications of Human Genetics, one must grasp its scientific foundations. We will approach these topics using: lectures, textbook, journal and newspaper readings, precept discussions, and patient interviews. We will consider the following subjects: gene structure and function; the genetics and genomics of populations and of selected human disorders (cancer, mental illness, metabolic diseases); and clinical genetics (inheritance patterns, diagnosis, treatment).