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A discussion of synthetic biology, computational issues in modeling cellular systems, and the engineering of biochemical computing systems. Topics include modeling of genetic regulatory networks using continuous and stochastic methods, construction of synthetic gene networks, metabolic networks, signal transduction pathways, cell-to-cell signaling, molecular and DNA computing, molecular self-assembly, directed molecular evolution, transcriptional and translational regulation, oscillation and circadian clocks, cell differentiation and pattern formation, chemotaxis, molecular switches and molecular electronics, theory of chemical computation.