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Spring 2011-2012
* MOL 430 (STN)  

The Power and Peril of Cycling Cells

Hilary A. Coller
Yibin Kang

Accurate control of cell cycle is essential for the formation and maintenance of a normal living organism. This course will study the molecular machinery that controls the cell cycle and the devastating consequence of its de-regulation that leads to cancer. We begin with a mechanistic examination of the cell cycle in bacteria, yeast, flies and mammals. We then consider cell cycle and cell size, and the cell cycle of stem cells. We will also discuss the oncogenic events that disrupt the normal cell cycle, the signaling pathways that activate uncontrolled cell proliferation, and the molecular therapeutics that target oncogenic pathways.

Sample reading list:
Beach, Nurse, Functionally homologous cell cycle control genes in yeast
Lohka, Maller, Purification of Maturation-Promoting Factor
Evans, Hunt, Cyclin: a protein specific by maternal RNA

Reading/Writing assignments:
Students will read 1-2 primary research papers relevant to the topic of each class, and answer questions about the papers. Students will be required to write essays regarding normal and aberrant cell cycle control for both halves of the semester. Students will be expected to read 20-30 pages per week.

Requirements/Grading:
Papers - 40%
Oral Presentation(s) - 35%
Other (See Instructor) - 25%

Schedule/Classroom assignment:

Class numberSectionTimeDaysRoomEnrollmentStatus
41624 L01 1:30 pm - 2:50 pm M W   Thomas Laboratory   317   Enrolled:7 Limit:30