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A detailed review of recent successes and failures in the discovery of new drugs. Therapeutic areas to be discussed include: HIV, oncology, asthma, Alzheimer's Disease, antibiotics, diabetes, and neglected diseases (malaria, TB, human African Trypaonosomiasis). Case studies presented by leading pharmaceutical scientists will complement discussions of the functional steps required to select a target, indentify a new chemical entity, and get it to patients. The course will emphasize the integration of the molecular sciences and the role of chemistry in inventing and producing important new medicines.