Drug Discovery in the Genomics Era
A detailed review of recent successes and failures in the discovery of new drugs. Therapeutic areas to be discussed include: HIV, oncology, asthma, Alzheimer's Disease, antibiotics, diabetes, and neglected diseases (malaria, TB, human African Trypaonosomiasis). Case studies presented by leading pharmaceutical scientists will complement discussions of the functional steps required to select a target, indentify a new chemical entity, and get it to patients. The course will emphasize the integration of the molecular sciences and the role of chemistry in inventing and producing important new medicines.
Sample reading list:
See instructor for complete list
Readings from the current literature.
Take Home Mid term Exam - 35%
Take Home Final Exam - 35%
Papers - 15%
Class/Precept Participation - 15%
Open to Juniors, Seniors, and Graduate Students Only.
Prerequisites and Restrictions:
Two semesters of organic chemistry (CHM 301 & 302 OR CHM 303 & 304/304B) or the equivalent..
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