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This course will provide an overview of several approaches to implementing quantum information and computation. It will touch briefly on quantum algorithms, but the main focus will be physical systems. In particular, the course will discuss what makes a good quantum system, the physics behind the leading implementations, and the limitations on each. Topics covered will include superconducting qubits, electron and nuclear spin qubits, and ion trap qubits, as well as descriptions of gate-based, adiabatic, and topologically protected quantum architectures.