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An overview of several approaches to implementing quantum information and computation, touching briefly on quantum algorithms, but focusing mainly on physical systems. In particular, the course discusses what makes a good quantum system, the physics behind the leading implementations, and the limitations on each. Topics covered will include superconducting qubits, electron and nuclear spin qubits, and ion trap qubits, as well as descriptions of gate-based, adiabatic, and topologically protected quantum architectures.