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This course covers the brain control of movement with an emphasis on how the cerebral cortex of the primate brain coordinates meaningful behavior. The topics range from the low-level control of muscles by motor cortex and the spinal cord, to the highest levels of interaction between the motor system and cognitive function. For example, the machinery for motor control may play a direct role in social cognition. The course begins with the discovery of motor cortex in 1870. It then covers a network of cortical and subcortical areas that together control movement and guide movement on the basis of cognitive decision and sensory input.