MOL 459 (STN)
Viruses: Strategy and Tactics
Viruses are unique parasites of living cells and may be the most abundant, highest evolved life forms on the planet. The general strategies encoded by all known viral genomes are discussed using selected viruses as examples. The first half of the course covers the molecular biology (the tactics) inherent in these strategies. The second half introduces the biology of engagement of viruses with host defenses, what happens when viral infection leads to disease, vaccines and antiviral drugs, and the evolution of infectious agents and emergence of new viruses.
Sample reading list:
Lombardi VC, et al, Science 2009 326:585-589
UNAIDS/WHO. 2007 AIDS Epidemic, Available at http://www.unaids.org
Joseph G. Victoria, et al, J. Virology, 2009 83: 4642-4651
Tumpey, TM, et al, Science 2005 310: 77-80
Marsh, M & Helenius, A., Cell 2006 124: 729-740.
Arhel, N. et al, Nature Methods 2006 3: 817-824.
See instructor for complete list
Assigned readings from literature or selected texts prior to class discussion.
Mid Term Exam - 35%
Final Exam - 50%
Class/Precept Participation - 15%
Not Open to Freshmen.
Prerequisites and Restrictions:
MOL 342 or MOL 348 or Permission of Instructor. No courses in the biological sciences or other departmental courses may be taken pass/D/fail by molecular biology concentrators..
Graduate students will take the midterm written exam, but will write a paper on selected topics in virology in lieu of a final exam. Graduate students also attend a separate preceptorial session lead by a postdoctoral fellow where seminal papers in virology are analyzed and discussed.
|21432||L01||11:00 am - 11:50 am||M W F||Schultz Laboratory 107||Enrolled:20 Limit:65|
|P01||7:30 pm - 8:50 pm||M||Thomas Laboratory 005||Enrolled:15 Limit:20|
|P02||7:30 pm - 8:50 pm||T||Thomas Laboratory 117||Enrolled:4 Limit:20|