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Course Details

Spring 2015-2016
MOL 523   No Pass/D/Fail

Molecular Basis of Cancer

Yibin Kang

We explore the molecular events leading to the onset and progression of human cancer. We review the central genetic and biochemical elements that make up the cell cycle, followed by a survey of the signal transduction pathways and checkpoints that regulate it. We discuss oncogenes, tumor suppressor and mutator genes that act in these pathways and review the role of viral oncogenes and their action on cells. We investigate the role of cancer stem cells and the interaction between tumor and the host environment. We explore specific clinical case studies in light of the molecular events underlying different cancers.

Sample reading list:
R. Weinberg, The Biology of Cancer, Garland Science (2013)

Reading/Writing assignments:
Students will be required to read two primary research papers, 1-2 review papers and the related book chapter before each class. Each student will also make an oral presentation on one of the topics during the class. As the final assignment, students are required to write a commentary review on a recent cancer research paper

Requirements/Grading:
Paper in lieu of Final - 40%
Oral Presentation(s) - 30%
Class/Precept Participation - 30%

Other Requirements:
Not Open to Freshmen.

Other information:
Course will meet twice a week for sessions devoted in part to lectures and in part to class discussion analyzing current research topics taken from the primary research literature.

Website:  http://blackboard.princeton.edu/pucourse/MOL523_S2014

Schedule/Classroom assignment:

Class numberSectionTimeDaysRoomEnrollmentStatus
41770 L01 1:30 pm - 2:50 pm T F        Enrolled:3 Limit:6