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Course Details

Fall 2017-2018
QCB 515 / PHY 570 / EEB 517 / CHM 517 / MOL 515   Graded A-F, P/D/F, Audit

Method and Logic in Quantitative Biology

Ned S. Wingreen

Close reading of published papers illustrating the principles, achievements, and difficulties that lie at the interface of theory and experiment in biology. Two important papers, read in advance by all students, will be considered each week; the emphasis will be on discussion with students as opposed to formal lectures. Topics include: cooperativity, robust adaptation, kinetic proofreading, sequence analysis, clustering, phylogenetics, analysis of fluctuations, and maximum likelihood methods. A general tutorial on Matlab and specific tutorials for the four homework assignments will be available.

Sample reading list:
Barkai, N. and Leibler, S., Robustness in Simple Biochemical Networks
Luria, S. E. and Delbruck, M., Mutations of Bacteria from Virus Sensitivity to Virus...
Goldbeter, A. and Koshland D. E. Jr, An Amplified Sensitivity Arising from Covalent...
Hopfield, J. J., Kinetic Proofreading: A New Mechanism for Reducing Errors...
Smith, T.F. and Waterman, M.S., Identification of Common Molecular Subsequences

Quizzes - 25%
Class/Precept Participation - 50%
Other (See Instructor) - 25%

Prerequisites and Restrictions:
Prior knowledge of calculus (differential equations) and linear algebra..

Other information:
This course is intended for graduate students interested in quantitative/computational biology. Undergraduates may enroll only with prior approval from one of the instructors.

Schedule/Classroom assignment:

Class numberSectionTimeDaysRoomEnrollmentStatus
21600 S01 1:30 pm - 4:30 pm T        Enrolled:8 Limit:30