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Course Offerings

Course Evaluation Results

Course Details

Fall 2011-2012
MOL 440 (STN)   Graded A-F, P/D/F, Audit

Genome Integrity and Human Disease

Virginia A. Zakian


This seminar style course will focus on the basic science that provides the background for understanding diseases caused by defects in chromosome maintenance. Readings will be in the primary literature, and classroom participation will be a key part of the course. Topics will include telomeres, trinucleotide repeats, DNA damage check points, tumor susceptibility genes, and chromatin modification.

Sample reading list:
Greider CW, Blackburn EH. 1985 Cell. 43:405-13., Identification of a specific telomere terminal transferase
activity in Tetrahymena extracts.
Blasco MA, et al. 1997 Cell. 91:25-34., Telomere shortening and tumor formation by mouse cells
lacking telomerase RNA.
Mitchell JR, Wood E, Collins K. 1999 Nature. 402:551-5, A telomerase component is defective in the human disease
dyskeratosis congenita.
See instructor for complete list

Reading/Writing assignments:
Students will read around 20 pages weekly, depending on the degree of difficulty as well as the size and number of illustrations. Students will be expected to write a two page paper that summarizes the paper from the primary literature assigned for that day.

Final Exam - 35%
Papers - 30%
Class/Precept Participation - 35%

Other Requirements:
Not Open to Freshmen.

Other information:
Class size is limted to 10. Contact instructor for permission to enroll.

Schedule/Classroom assignment:

Class numberSectionTimeDaysRoomEnrollmentStatus
20925 S01 03:00:00 pm - 04:20:00 pm M W   Thomas Laboratory   117   Enrolled:4 Limit:10