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Course Details

Fall 2016-2017
MOL 559   Graded A-F, P/D/F, Audit

Viruses: Strategy and Tactics

Lynn W. Enquist

Viruses are unique parasites of living cells and may be the most abundant, highest evolved life forms on the planet. The general strategies encoded by all known viral genomes are discussed using selected viruses as examples. The first half of the course covers the molecular biology (the tactics) inherent in these strategies. The second half introduces the biology of engagement of viruses with host defenses, what happens when viral infection leads to disease, vaccines and antiviral drugs, and the evolution of infectious agents and emergence of new viruses.

Sample reading list:
Brandenburg and Zhuang, Virus trafficking-learning from sinble virus tracking
Mercer and Helenius, Vaccinia virususes macropinocytosis and apoptotic mimicry to
Atmar, Noroviruses-state of the art
Spurgeon and Lambert, Merkel cell polyomavirus:a newly discovered human virus with
Elde et al, Poxviruses deploy genomic accordions to adapt rapidly agains
Lecuit and Eloit, The human virome: new tools and concepts
See instructor for complete list

Reading/Writing assignments:
Assigned readings from literature or selected texts prior to class discussion

Requirements/Grading:
Mid Term Exam - 35%
Other Exam - 50%
Class/Precept Participation - 15%

Other Requirements:
Not Open to Freshmen.

Other information:
Graduate students will take the midterm written exam, but will write a paper on selected topics in virology in lieu of a final exam. Graduate students will also attend a separate preceptorial session lead by a postdoctoral fellow where seminal papers in virology are analyzed and discussed.

Schedule/Classroom assignment:

Class numberSectionTimeDaysRoomEnrollmentStatus
22386 L01 11:00 am - 11:50 am M W F   Schultz Laboratory   107   Enrolled:1 Limit:15
22450 P01 3:30 pm - 4:20 pm M   Schultz Laboratory   318   Enrolled:1 Limit:15